Connor A. Lowey

Works by this author

Language: English

Visualizing the Degradation of pRb by the High-Risk HPV Protein E7

Connor A. Lowey
Andrew C. Greer
Visualizing the Degradation of pRb by the High-Risk HPV Protein E7

The oncoprotein E7 coded for by the human papillomavirus (HPV) is known to degrade the tumor suppressor retinoblastoma protein (pRb). Transient transfections of a plasmid coding for the E7 protein were not effective at visualizing degradation of pRb. Although transient transfection would be efficient in visualizing pRb degradation, the lack of success makes more reliable methods, such as the use of retroviruses, necessary.

The oncoprotein E7 coded for by the human papillomavirus (HPV) is known to degrade the tumor suppressor retinoblastoma protein (pRb). Transient transfections of a plasmid coding for the E7 protein were not effective at visualizing degradation of pRb. Although transient transfection would be efficient in visualizing pRb degradation, the lack of success makes more reliable methods, such as the use of retroviruses, necessary.
English
Type: 
Research paper
WHDL ID: 
WHDL-00018761